Forget ALS Guidelines when dealing with PEA. Part 2.
23 Sep
In Part 1 we discussed about diagnosis and diagnostic tools. Here are suggested alternative way to evaluate and treat patients with PEA.
Forget ACLS guidelines if you are dealing with Pulseless Electric Activity. Part 1.
5 Sep
ACLS Guidelines are misleading about diagnosis and treatment of pulseless electric activity (PEA)
This takes to conceptual and clinical errors when treating patients in cardiac arrest.
Let’s see why and if there is a better way to follow when dealing with this kind of patients.
First part is about diagnosis and diagnostic tools.
Live your comment below and see you soon for Part 2. The treatment options.
NICE released Major Trauma Guidelines Draft.
8 Aug
The National Institute for Health and Care Excellence (NICE) published a Guidelines Draft on Major Trauma. The great thing about is that everyone can consult the draft and send suggestion (but only if you work for a stackholder organization) about the recommendations and scientific evidences contained.
Consult the documents at the links below:
- Major trauma: assessment and initial management full guidelines
- Major trauma: assessment and initial management short version, just the recommendations
- Evidence in full (appendices)
Here are some highlights with a particular regard to pre-hospital environment recommendations:
Airway management
RSI and orotracheal intubation is the preferred method to manage airways (when compromised) in a trauma patient.
In prehospital setting RSI and OTI has to be performed on scene in less than 30 min from the initial call. Backup plan is SGA (in patients with reduced level of consciousness and no glottic reflexes) or basic airways maneuver plus adjuncts (patients with GAG reflexes still present), and transfer to Trauma Center (within 60 min) to manage airways. If Trauma Center is more than 60 minutes away, reach local hospital to perform RSI and than transfer the patient.
“The GDG had a strong belief that RSI of anaesthesia and intubation delivered by a competent person is the gold standard of care when maintaining the airway of both adults and children and made a recommendation for RSI of anaesthesia and
intubation accordingly.”
“The GDG suggested that the second best device for airway management was the supraglottic device. This device provides less protection than RSI of anaesthesia and intubation against aspiration; however this device provides greater protection than
basic airway adjuncts, and can be administered safely by in the pre-hospital environment by paramedics or physicians staff.”
“Supraglottic devices can only be used in patients without airway reflexes to avoid stimulating vomiting or laryngospasm,, and
are therefore only appropriate for use in patients with a reduced level of consciousness.”
“For patients with airway reflexes, where a supraglottic device cannot be used, the GDG recommended the use of basic airway manoeuvres and adjuncts until such time as RSI of anaesthesia and intubation is available.”
“The GDG therefore concluded that where possible, RSI should be delivered at scene and within a timeframe than minimised
pre-hospital time. Pre-hospitals systems should develop to make this widely available. Where pre-hospital RSI is not possible within a 30-minute window, the GDG recommended transporting the patient with supraglottic or basic airway adjuncts to a MTC within 60 minutes, otherwise to a TU”
Pre-hospital Tension Pneumothorax
- Closed pneumo
Perform chest decompression of a suspected tension pneumothorax only in haemodynamically unstable patients or in pts who have respiratory compromise.
Perform open thorachostomy to drain tension pneumothorax in haemodynamically unstable patients (preferred on simple needle decompression).
Simple open thorachostomy can be performed only in intubated (and positive pressure ventilated) patients. In all other cases insert a chest drain to prevent a sucking chest open wounds
- Open pneumo
No more vented or 3-sided occlusive dressing in open (sucking) pneumothorax: use a simple occlusive dressing to treat an open pneumothorax in the pre-hospital setting
“The GDG limited the recommendation to intervene to people who are haemodynamically unstable or have severe respiratory compromise. The GDG agreed that people who have signs of a tension pneumothorax but are haemodynamically normal can wait until hospital for a more definitive diagnosis and possible decompression.”
“Needle decompression is a simpler technique to perform than insertion of a chest drain but is associated with a number of complications. These include the cannula blocking, the catheter not being long enough and therefore, not penetrating the
thoracic parietal pleura, or incorrect placement of the needle, all of which result in the decompression not being successful. The GDG agreed by consensus that open thoracostomy is more effective and stable than needle decompression.”
“An open thoracostomy can only be used on intubated patients. A surgical incision is made, blunt dissection is performed, and the pleura penetrated. The wound is then left open. This is a rapid way of decompressing a tension pneumothorax in a critically injured trauma patient who is intubated. The positive pressure ventilation prevents the thoracostomy wound from acting as an open, ‘sucking’, chest wound”
“The GDG agreed that given the lack of evidence, no recommendation could be made around whether an occlusive dressing for an open pneumothorax should be vented or three-sided. Additionally, the GDG accepted there was no evidence to make a
recommendation around supplementing the dressing with a chest drain in the prehospital setting.The GDG decided through expert consensus to recommend using a simple occlusive dressing to treat an open pneumothorax in the pre-hospital setting. The GDG emphasised the importance of a ‘simple’ dressing that provides an airtight seal that is fast and straightforward to apply. The priority should be transporting the patient to a hospital where a chest drain can be inserted.”
Haemorrhage control
First line intervention is direct pressure with simple dressing.
If direct pressure failed use tourniquets (no difference between mechanical or penumatic ones) as backup method. Is controversial when tourniquets has to be used (as first line) over direct pressure
Use Tranexamic acid in suspected haemorrahagic patients as soon as possible but never beyond 3 hrs from trauma
“In the absence of any evidence in favour of haemostatic dressings, the GDG did not believe that they offered any improvement over and above standard dressings with direct pressure.”
“Whereas, immediate haemorrhage control can be achieved by direct pressure, the decision of when direct pressure should be
used over tourniquets was considered controversial as the GDG tried to weigh up the risk and cost of placing a tourniquet on a person who did not require it compared with those that do.”
Vascular access
In adults use IV access as first line and IO as rescue technique if IV failed
In children, when difficult vascular access is suspected, use IO access as first line technique
Fluid resuscitation
In pre-hospital environment the target for volume titration has to be maintaining a palpable central pulse (femoral or carotid)
In pre-hospital, if blood products are not available, small boluses of crystalloids are the preferred fluid volume replacement.
“The GDG discussed the situation when a pre-hospital practitioner is treating a patient in profound haemorrhagic shock but does not have access to blood products. In this case small boluses of crystalloids would be appropriate.”
Pain control
IV Morphine is the first line recommended agent. Ketamine (at pain relief doses) the second option.
Caution is recommended when Morphine is administered in a haemodinamically unstable patient.
Intranasal administration is the recommended route of administration when IV is not available.
“Two studies compared IV morphine with IV fentanyl and found no difference between the interventions for pain relief and adverse side effects.”
(Many) Things that I Like about these guidelines
-
The airway management approach! Totally agree on RSI and OTI as gold standard in trauma, and if performed, better be fast. The 30 min target is a quite fair indication but, as any other straight timing, depends on the circumstances. The thing I appreciate is the idea of DO IT IN THE SHORTEST TIME POSSIBLE. Great. And if plan A (Ventilation+Oxygenation) fails? Plan B (Oxygenate) SGA and rush to TC, if close, or to any other trauma unit. And if for any reason placing a SGA is not possible? Use BVM and adjuncts and rush again. Love it!
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Thoracostomy better than needle decompression, both in prehospital and in hospital, for tension pneumothorax drainage. We are all aware of the bunch of studies indicating as needle decompression is inadequate in most cases, and all the FOAMED drums are rumbling on these frequencies. But till now none (first of all the Archaic Trauma Life Support) officially stated this in a guideline (that I’m aware to, at least). So WELCOME expert consensus of NICE GDG!
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Simple occlusive dressing in open pneumo. Straight and simple.
-
The choice for prehospital fluid replacement goes on crystalloids only cause blood products are not available, but in the text is highlighted as both crystalloids and colloids are detrimental on coagulation process (so they are banned in hospital setting). The future is blood products even in prehospital environment!
(Few) Things that I don’t like about these guidelines
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The choice of open simple thoracostomy just in intubated pts has to be more clearly highlighted. I suggest as an adjunct to main (yellow background) recommendation. And so as to be for thoracostomy plus chest drainage in non intubated pts.
-
Why they just mention Morphine (as opioid) for pain control and don’t include fentanyl in the main recommendation, if in the text is clearly indicated as all the available evidences show no differences between the two drugs in terms of clinical effects and adverse events? I think Fentanyl due to its wide diffusion (with great satisfaction) worths a mention!
Draft closes for comments on 21 of September.
My favourite VL view to increase first pass intubation
8 FebA debate is ongoing among #FOAMED social media about increasing first passage rate in tracheal intubation and some difficulties when using VL.
At the beginning of my experience with VL I experienced some difficulties, but with a radical change in technical approach I reached a good security on first pass success.
Here are my consideration and I hope will be useful for anyone is starting using VL
There are some fundamental differences in VL technique respect to DL, that makes the DL more easy and intuitive to pass the tube trough the cords.
“Sniffing position” align the pharyngeal axis with the laryngeal one
Perfoming Direct Laryngoscopy with the laryngoscope we align the mouth axis to have a direct view of the cords.
This view coincide with the route for passing the tube, making this step intuitive and easy.
When using a Video Laryngoscope we take our eyes right in front of the larynx, having a perfect “video” view of the vocal cords, but also minimally modifying the axis of the mouth.
This difference makes the act of passing the tube not so easy and not so intuitive, cause of the contrast between the perfect video laryngeal view and the not easy passage of the tube trough the cords.
In those cases the stylet, the Bougie/Froban or the external glottic maneuvers, are useful to facilitate the video-intubation.
But the first goal is to reach this view on the screen of the videolaryngoscope.
I want to have the epiglottis right at the center of the screen and this comes prior of a good view of the larynx.
Epiglottoscopy is the key point of my management of the airways in general and when prforming VL in particular.
Having the epiglottis in central position on the screen allow to:
- lower the glottic plane facilitating intubation
- decrease the force to apply on the airways minimizing traumatism and neck movement in case of trauma.
- fits all the difficult airway situations because a poor view of the cords is what you are looking for!
If you agree, memorize my favorite view and reach for it when using a video device to mange the airways.
All comments are welcome so please let me know your thoughts.
F.A.R. in E.M. (Focus Assessed Review in Emergency Medicine ) #4: Stroke. Bonus feature, 2015 ACEP Clinical Policy on Use of Intravenous tPA for the Management of Acute Ischemic Stroke in the Emergency Department
27 Jan
And here we are with the 4th episode of the F.A.R. series. If you accidentally lost the first two episodes you can find them here:
#1 Cardiac Arrest
#2 Airway Management
In this episode we’ll explore the best articles of 2014 about:
Stroke
Before starting we have to declare (if you are not aware of) that MEDEST is quite skeptical about the previous studies that are at the basis of thrombolytic therapy (Lo strano caso del trombolitico nell’ictus cerebrale ischemico, Pubblicate le nuove linee guida AHA/ASA sul trattamento precoce dello Stroke: nessuna nuova ed ancora qulache dubbio!, L’uso del trombolitico nello stroke. Stiamo giocando con la salute dei nostri pazienti?, rt-PA e Stroke: IST-3 l’analisi dei risultati). This can represent a potential bias on the choice of the articles. We also think that the actual evidences, and the consequent guidelines, are strongly influenced by commercial interests and not well supported from evidences that demonstrates how benefits outweight harms. We hope that 2015 will be the first year of a new era for stroke management, an era of well done studies producing strong evidences to achieve good neurological targets in all stroke patients.
In the first part we mention the litterature about thrombolytic therapy
- Thrombolytic Therapy in Acute Stroke
- Questions about authorisation of alteplase for ischaemic stroke
- Door-to-Needle Times for Tissue Plasminogen Activator Administration and Clinical Outcomes in Acute Ischemic Stroke Before and After a Quality Improvement Initiative
- Time to treatment with recombinant tissue plasminogen activator and outcome of stroke in clinical practice
- Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials
- Association Between Hyperoxia and Mortality After Stroke- A Multicenter Cohort Study
And then the articles about endovascular therapy:
- A meta-analysis of prospective randomized controlled trials evaluating endovascular therapies for acute ischemic stroke
- A research roadmap of future endovascular stroke trials
- Endovascular therapy for acute ischemic stroke is indicated and evidence based: a position statement
- Reperfusion therapies of acute ischemic stroke: potentials and failures
- Stroke- an emphasis on guidelines
- A Randomized Trial of Intraarterial Treatment for Acute Ischemic Stroke
- Prehospital Stroke Care: Limitations of Current Interventions and Focus on New Developments
And now as anticipated in the title the 2015 ACEP Clinical Policy on Use of Intravenous tPA for the Management of Acute Ischemic Stroke in the Emergency Department. Those freshly published guidelines give answer at two of most recurrent questions on stroke treatment:
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Is IV tPA safe and effective for acute ischemic stroke patients if given within 3 hours of symptom onset?
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Is IV tPA safe and effective for acute ischemic stroke patients treated between 3 to 4.5 hours after symptom onset?
Download and read the full policy to discover the recommendations made and based on the strength of the available data.
DISCLOSURE: MEDEST strongly encourage AWARNESS reading the propoused articles.
Abstracts are often misleading and articles potentially biased. Even this selection is not immune from potential bias (just human factors not commercial interests).
So download the full text and read it carefully to have a clear and complete opinion of the related topics.
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F.A.R. in E.M. (Focus Assessed Review in Emergency Medicine ) #3: Trauma
10 Jan
And here we are with the 3th episode of the F.A.R. series. If you accidentally lost the first two episodes you can find them here:
#1 Cardiac Arrest
#2 Airway Management
In this episode we’ll explore the best articles of 2014 about:
Trauma
Before approaching specific arguments about trauma here are some fundamental articles to read about new emerging concepts in trauma care. Those are the clinical and physiological bases to understand what is happening in the actual trauma management scene.
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Trauma-Induced Coagulopathy
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Development of a simple algorithm to guide the effective management of traumatic cardiac arrest (read also Mind of resuscitation in traumatic cardiac arrest)
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Damage Control Resuscitation in Trauma
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The Management of Pediatric Polytrauma: Review
And now let’s go to specific area of interest:
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Spine immobilization
Spine immobilization in trauma is changing.
After years of dogmatic approach to strict spine immobilization for all trauma patients regardless any other factor, is now pretty clear that not all the trauma patients benefits from this all or nothing way of thinking. MEDEST already faced the argument in previous posts (The Death of the Cervical Collar?) as also did some prehospital consensus guidelines (Faculty of Pre-Hospital Care Consensus Statements).
In 2014 many articles treated this topic in a critical and modern way of re-thinking spinal immobilization, in particular the widespread use of cervical collar. The lessons we learned is that:
- Widespread use of cervical collar in neck trauma has to be carefully evaluated (and even avoided) due to the low incidence of unstable spinal lesions.
- Routine use of cervical collar is of unclear benefit and supported by weak evidences. A new selective approach has to be implemented based on prehospital clearance protocols.
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Cost-utility analysis of prehospital spine immobilization recommendations for penetrating trauma
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Learning the lessons from conflict: Pre-hospital cervical spine stabilisation following ballistic neck trauma
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Prehospital Use of Cervical Collars in Trauma Patients- A Critical Review
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Comparison of Three Prehospital Cervical Spine Protocols for Missed Injuries
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Fluids and blood products
What is “revolution” in clinical practice? We don’t have the answer to this dilemma, but what is happening in fluid resuscitation for trauma patients seems likely to be revolutionary. Restrictive strategies and new blood products are the future for the treatment of trauma patients (read also Fluid resuscitation in bleeding trauma patient: are you aware of wich is the right fluid and the right strategy?).
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Liberal Versus Restricted Fluid Resuscitation Strategies in Trauma Patients
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Fluid resuscitation in trauma patients- what should we know
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Pretrauma Center Red Blood Cell Transfusion Is Associated With Reduced Mortality and Coagulopathy in Severely Injured Patients With Blunt Trauma
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The Ongoing Debate Between Crystalloid and Colloid
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Fluid Resuscitation for Trauma Patients: Crystalloids Versus Colloids
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Hypotensive Resuscitation
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Trauma and Massive Blood Transfusions
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Is early transfusion of plasma and platelets in higher ratios associated with decreased in-hospital mortality in bleeding patients?
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The Prospective, Observational, Multicenter, Major Trauma Transfusion (PROMMTT) Study
But much more happened in 2014 about trauma….
Resuscitative throacotomy is now a reality not only “in” but even “out” of hospital, so read all about it
An evergreen topic is TBI but new concepts are arousing so read here the latest updates
New drugs and new protocols for airway and pain management: a rationale guide to choose the right drug for the right patient.
DISCLOSURE: MEDEST strongly encourage AWARNESS reading the propoused articles.
Abstracts are often misleading and articles potentially biased. Even this selection is not immune from potential bias (just human factors not commercial interests).
So download the full text and read it carefully to have a clear and complete opinion of the related topics.
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F.A.R. in E.M. (Focus Assessed Review in Emergency Medicine ) #2
5 Jan
The second episode of this focus reviews will deeply assess a topic that is very “hot” for every emergency professional.
Before reading this episode give a look at the first of the series about the best of 2014 literature on Cardiac Arrest
And now enjoy the very best of 2014 articles on:
Airway Management
Not all is CRASH! Especially when it comes to airway management. RSI is the gold standard when we talk about intubating a spontaneously breathin patient but DSI is becoming a classic. And is recommended by Scott Weingart and Seth Trueger, not properly two “new kids on the block”….
- Prehospital Rapid Sequence Intubation Improves Functional Outcome for Patients With Severe Traumatic Brain Injury
- Delayed Sequence Intubation: A Prospective Observational Study
Caution! You are about to perform an invasive maneuver on a previously spontaneously breathing patient. So remember to carefully avoid desaturation and hyper-inflation!
This disclaimer should be written on the handle of every laryngoscope to remember two of the most frequent fault to avoid when managing the airways.
- Apnoea and pre-oxygenation
- Avoiding Circulatory complications during Intubation
- Regarding Hemodynamic Responses During Orotracheal Intubation: A Randomized Controlled Trial
Always rewarded as a nightmare for the emergency professional, surgical airway is most of the time a real no through road for the patient. So here is a complete guide on how to approach in the best way such a difficult skill.
Does the aggressive management of the airways gets benefits on critically ill patients or a more conservative approach gives best results on clinical outcomes? Facts (few) and doubts (many) in this year literature.
- Airway management and out-of-hospital cardiac arrest outcome in the CARES registry
- Observational study of the success rates of intubation and failed intubation airway rescue techniques in 7256 attempted intubations of trauma patients by pre-hospital physicians
- Outcomes following prehospital airway management in severe traumatic brain injury
DISCLOSURE: MEDEST strongly encourage AWARNESS reading the propoused articles.
Abstracts are often misleading and articles potentially biased. Even this selection is not immune from potential bias (just human factors not commercial interests).
So download the full text and read it carefully to have a clear and complete opinion of the related topics.
Follow MEDEST on Google+
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F.A.R. in E.M. (Focus Assessed Review in Emergency Medicine ) #1
2 Jan
This is the first (of a series) of literature reviews dedicated to a particular topic of Emergency Medicine clinical life.
We tried to give a deep look to all the articles that had a relevance for a particular argument in this year, and made some considerations regarding the emerged evidences . All the articles are full text end ready to be downloaded.
The first edition is focused on the “king argument” for an emergency medicine and critical care professional:
Cardiac Arrest
Chest compressions
This year the importance of chest compressions in CA was confirmed and even emphasized as one of the few (along with defibrillation) really wothy intervention to perform during CPR.
- Chest Compression Alone Cardiopulmonary Resuscitation Is Associated With Better Long-Term Survival Compared with Standard Cardiopulmonary Resuscitation
- Chest compression depth and survival in out-of-hospital cardiac arrest
Mechanical Devices
The “black year” for mechanical devices saw 3 major trials finding no difference in outcome between mechanical and (good quality) manual chest compressions. Still remains the subjective (personal) impression that mechanical devices are of some utility for the human resources management and transport during CPR.
- Manual vs. integrated automatic load-distributing band CPR with equal survival after out of hospital cardiac arrest. The randomized CIRC trial
- Mechanical chest compressions and simultaneous defibrillation-vs-conventional cardiopulmonary resuscitation in-out-of-hospital cardiac arrest The LINC RCT
- Do Mechanical Devices Improve Return of Spontaneous Circulation Over Manual Chest Compressions in Out-of-Hospital Cardiac Arrest
- Prehospital Randomized Assessment of a Mechanical Compression Device in Cardiac Arrest (PARAMEDIC)
Vasoactive (and other) drugs
Like (and perhaps more) than for mechanical devices, 2014 signed a really bad year for epinephrine.
Lack of evidence on his utility and emerging ones on detrimental effects, accompanied this “historical” drug through the year that preludes to new 2015 CA Guidelines. Will epinephrine still be there at the end of this 2015? Or new emerging trends on use of steroids and vasopressin will prevale at the end?
- Vasopressin, Steroids, and Epinephrine and Neurologically Favorable Survival After In-Hospital Cardiac Arrest
- Epinephrine, vasopressin and steroids for in-hospital cardiac arrest: the right cocktail therapy?
- Glucocorticoids as an Emerging Pharmacologic Agent for Cardiopulmonary Resuscitation
- Epinephrine in Cardiac Arrest and Patients Outcomes
- Adrenaline for out-of-hospital cardiac arrest resuscitation- A systematic review and meta-analysis of randomized controlled trials
- Adrenaline (epinephrine) dosing period and survival after in-hospital cardiac arrest- A retrospective review of prospectively collected data
- Time to administration of epinephrine and outcome after in-hospital cardiac arrest with non-shockable rhythms: retrospective analysis of large in-hospital data registry
- Does Calcium Administration During Cardiopulmonary Resuscitation Improve Survival for Patients in Cardiac Arrest?
ECLS
And after interventions that are loosing evidence in the years, new future prospectives for the management of CA patients, comes from Extra-Corporeal Membrane Oxygenation that gives renewed hopes of better survival and good neurological outcome, despite initial difficulties and skepticism.
- Extracorporeal cardiopulmonary resuscitation versus conventional cardiopulmonary resuscitation in adults with out-of-hospital cardiac arrest- A prospective observational study
- An optimal transition time to extracorporeal cardiopulmonary resuscitation for predicting good neurological outcome in patients with out-of-hospital cardiac arrest- a propensity-matched study
Outcome and prognostication
- Exploring which patients without return of spontaneous circulation following ventricular fibrillation out-of-hospital cardiac arrest should be transported to hospital
- Predicting the lack of ROSC during pre-hospital CPR- Should an end-tidal CO 2 of 1.3 kPa be used as a cut-off value
- Shorter time until return of spontaneous circulation is the only independent factor for a good neurological outcome in patients with postcardiac arrest syndrome
- Survival rates in out-of-hospital cardiac arrest patients transported without prehospital return of spontaneous circulation: An observational cohort study
- Trends in Short- and Long-Term Survival Among Out-of-Hospital Cardiac Arrest Patients Alive at Hospital Arrival
- Early coronary angiography and induced hypothermia are associated with survival and functional recovery after out-of-hospital cardiac arrest
- Angiography Urged in All Resuscitated Out-of-Hospital Cardiac Arrest
Therapeutic Hypothermia
New era for the post-resuscitative care! Less oxygen, lower tidal volume and last, but not least, less cooling. And, while this year will give us some answers about intra-arrest cooling, now we know that 33°C is equally effective as 36°C and is no longer recommended in post ROSC patients! Maybe….
- Effect of Prehospital Induction of Mild Hypothermia on Survival andNeurological Status Among Adults With Cardiac Arrest A Randomized Clinical Tria.pdf
- Targeted Temperature Management Processes and Outcomes After Out-of-Hospital Cardiac Arrest- An Observational Cohort Study
- From therapeutic hypothermia towards targeted temperature management: a decade of evolution
Other
Hypotermia (accidental not therapeutic), highlights from ERC 2014 Congress and decision on non starting CPR: what changes and what remains in our daily practice.
- Cardiac arrest from accidental hypothermia, a rare condition with potentially excellent neurological outcome, if you treat it right
- Resuscitation highlights- Part 1
- Resuscitation highlights- Part 2
- Current Opinion in Critical Care-Cardica Arrest
- Decisions Relating To CPR
- Hemodynamic–directed cardiopulmonary resuscitation during in–hospital cardiac arrest
DISCLOSURE: MEDEST strongly encourage AWARNESS reading the propoused articles.
Abstracts are often misleading and articles potentially biased. Even this selection is not immune from potential bias (just human factors not commercial interests).
So download the full text and read it carefully to have a clear and complete opinion of the related topics.

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MEDEST Review 30. One year in Review.
25 DecDISCLOSURE: MEDEST strongly encourage AWARNESS reading the propoused articles.
Abstracts are often misleading and articles potentially biased. Even this selection is not immune from potential bias (just human factors not commercial interests).
So download the full text and read it carefully to have a clear and complete opinion of the related topics.
The latest Review of the year is dedicated to a collection of the most important (for us) articles of this 2014.
This is MEDEST way to wish you all Merry Xmas.
Enjoy the reading:
Cardiac Arrest
Chest compression
- Chest Compression Alone Cardiopulmonary Resuscitation Is Associated With Better Long-Term Survival Compared with Standard Cardiopulmonary Resuscitation
- Chest compression depth and survival in out-of-hospital cardiac arrest
Mechanical Devices
- Manual vs. integrated automatic load-distributing band CPR with equal survival after out of hospital cardiac arrest. The randomized CIRC trial
- Mechanical chest compressions and simultaneous defibrillation-vs-conventional cardiopulmonary resuscitation in-out-of-hospital cardiac arrest The LINC RCT
- Do Mechanical Devices Improve Return of Spontaneous Circulation Over Manual Chest Compressions in Out-of-Hospital Cardiac Arrest
Vasoactive drugs
- Vasopressin, Steroids, and Epinephrine and Neurologically Favorable Survival After In-Hospital Cardiac Arrest
- Epinephrine, vasopressin and steroids for in-hospital cardiac arrest: the right cocktail therapy?
- Glucocorticoids as an Emerging Pharmacologic Agent for Cardiopulmonary Resuscitation
- Adrenaline for out-of-hospital cardiac arrest resuscitation- A systematic review and meta-analysis of randomized controlled trials
- Adrenaline (epinephrine) dosing period and survival after in-hospital cardiac arrest- A retrospective review of prospectively collected data
- Time to administration of epinephrine and outcome after in-hospital cardiac arrest with non-shockable rhythms: retrospective analysis of large in-hospital data registry
- Does Calcium Administration During Cardiopulmonary Resuscitation Improve Survival for Patients in Cardiac Arrest?
ECLS
- Extracorporeal cardiopulmonary resuscitation versus conventional cardiopulmonary resuscitation in adults with out-of-hospital cardiac arrest- A prospective observational study
- An optimal transition time to extracorporeal cardiopulmonary resuscitation for predicting good neurological outcome in patients with out-of-hospital cardiac arrest- a propensity-matched study
Outcome and prognostication
- Exploring which patients without return of spontaneous circulation following ventricular fibrillation out-of-hospital cardiac arrest should be transported to hospital
- Predicting the lack of ROSC during pre-hospital CPR- Should an end-tidal CO 2 of 1.3 kPa be used as a cut-off value
- Shorter time until return of spontaneous circulation is the only independent factor for a good neurological outcome in patients with postcardiac arrest syndrome
- Survival rates in out-of-hospital cardiac arrest patients transported without prehospital return of spontaneous circulation: An observational cohort study
- Trends in Short- and Long-Term Survival Among Out-of-Hospital Cardiac Arrest Patients Alive at Hospital Arrival
- Early coronary angiography and induced hypothermia are associated with survival and functional recovery after out-of-hospital cardiac arrest
- Angiography Urged in All Resuscitated Out-of-Hospital Cardiac Arrest
Therapeutic Hypothermia
- Effect of Prehospital Induction of Mild Hypothermia on Survival andNeurological Status Among Adults With Cardiac Arrest A Randomized Clinical Tria.pdf
- Targeted Temperature Management Processes and Outcomes After Out-of-Hospital Cardiac Arrest- An Observational Cohort Study
- From therapeutic hypothermia towards targeted temperature management: a decade of evolution
Other
- Cardiac arrest from accidental hypothermia, a rare condition with potentially excellent neurological outcome, if you treat it right
- Resuscitation highlights- Part 1
- Resuscitation highlights- Part 2
- Current Opinion in Critical Care-Cardica Arrest
- Decisions Relating To CPR
- Hemodynamic–directed cardiopulmonary resuscitation during in–hospital cardiac arrest
Trauma
Spine immobilization
- Cost-utility analysis of prehospital spine immobilization recommendations for penetrating trauma
- Learning the lessons from conflict- Pre-hospital cervical spine stabilisation following ballistic neck trauma
- Prehospital Use of Cervical Collars in Trauma Patients- A Critical Review
- Comparison of Three Prehospital Cervical Spine Protocols for Missed Injuries
Fluids and blood products
- Liberal Versus Restricted Fluid Resuscitation Strategies in Trauma Patients
- Fluid resuscitation in trauma patients- what should we know
- Pretrauma Center Red Blood Cell Transfusion Is Associated With Reduced Mortality and Coagulopathy in Severely Injured Patients With Blunt Trauma
- The Ongoing Debate Between Crystalloid and Colloid
- Fluid Resuscitation for Trauma Patients: Crystalloids Versus Colloids
- Hypotensive Resuscitation
- Trauma and Massive Blood Transfusions
- Is early transfusion of plasma and platelets in higher ratios associated with decreased in-hospital mortality in bleeding patients?
- The Prospective, Observational, Multicenter, Major Trauma Transfusion (PROMMTT) Study
Other
- Resuscitative thoracotomy an update
- Critical care management of severe traumatic brain injury in adults
- Choice of General Anesthetics for Trauma Patients
- Development of a simple algorithm to guide the effective management of traumatic cardiac arrest
- Damage Control Resuscitation in Trauma
- Trauma-Induced Coagulopathy
- Pre-hospital identification of trauma patients with early acute coagulopathy and massive bleeding: results of a prospective non-interventional clinical trial evaluating the Trauma Induced Coagulopathy Clinical Score (TICCS)
- Pain management in trauma patients in (pre)hospital based emergency care: Current practice versus new guideline
- The Management of Pediatric Polytrauma: Review
Airway management
- Prehospital Rapid Sequence Intubation Improves Functional Outcome for Patients With Severe Traumatic Brain Injury
- Avoiding Circulatory complications during Intubation
- Regarding Hemodynamic Responses During Orotracheal Intubation: A Randomized Controlled Trial
- Apnoea and pre-oxygenation
- Delayed Sequence Intubation: A Prospective Observational Study
- Advanced Airway Management Simulation Training in Medical Education- A Systematic Review and Meta-Analysis
- Surgical Management Of the Failed Airway: A Guide To Percutaneous Cricothyrotomy
- Airway management and out-of-hospital cardiac arrest outcome in the CARES registry
- Observational study of the success rates of intubation and failed intubation airway rescue techniques in 7256 attempted intubations of trauma patients by pre-hospital physicians
- Outcomes following prehospital airway management in severe traumatic brain injury
Sepsis
- Severe Sepsis and Septic Shock
- A Randomized Trial of Protocol-Based Care for Early Septic Shock
- Evaluation of 7.5 years of Surviving Sepsis Campaign Guidelines
- Goal-Directed Resuscitation for Patients with Early Septic Shock
ACS
- Pretreatment with Prasugrel in Non–ST-Segment Elevation Acute Coronary Syndromes
- Unfractionated Heparin vs Bivalirudin in Primary PCI- The HEAT – PPCI Trial
- ATLANTIC Prehospital Ticagrelor in ST-Segment Elevation Myocardial Infarction
- Reappraisal of thienopyridine pretreatment in patients with non-ST elevation acute coronary syndrome: a systematic review and meta-analysis
- Validation of an accelerated high-sensitivity troponin T assay protocol in an Australian cohort with chest pain
- Myocardial infarction (acute): Early rule out using high sensitive troponin
- The Manchester Acute Coronary Syndromes (MACS) decision rule for suspected cardiac chest pain derivation and external validation
- Third Universal Definition of Myocardial Infarction
- Efficacy and Safety of Out-of-Hospital Intravenous Metoprolol Administration in Anterior ST-Segment Elevation Acute Myocardial Infarction
Stroke
- Thrombolytic Therapy in Acute Stroke
- Questions about authorisation of alteplase for ischaemic stroke
- Door-to-Needle Times for Tissue Plasminogen Activator Administration and Clinical Outcomes in Acute Ischemic Stroke Before and After a Quality Improvement Initiative
- Time to treatment with recombinant tissue plasminogen activator and outcome of stroke in clinical practice
- Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials
- A Randomized Trial of Intraarterial Treatment for Acute Ischemic Stroke
- Prehospital Stroke Care: Limitations of Current Interventions and Focus on New Developments
- Association Between Hyperoxia and Mortality After Stroke- A Multicenter Cohort Study
Guidelines
- AHA:ASA Guideline on Stroke With Brain Swelling
- Clinical practice guideline on diagnosis and treatment of hyponatraemia
- GOLD Report 2014
- 2014 AHA/ACC Atrial Fibrillation Guidelines
- 2014 Focused Update of the Canadian Cardiovascular Society Guidelines for the Management of Atrial Fibrillation
- 2014 ESC Guidelines on the diagnosis and management of acute pulmonary embolism
- Guideline on Treatment of Patients with Severe and Multiple Injuries
- The Japanese guidelines for the management of sepsis
Emergency Pharmacology
- Lorazepam vs Diazepam for Pediatric Status Epilepticus
- The Effect of Ketamine on Intracranial and Cerebral Perfusion Pressure and Health Outcomes- A Systematic Review
- Prehospital analgesia using nasal administration of S-ketamine – a case series
- Prehospital Use of IM Ketamine for Sedation of Violent and Agitated Patients
- Anaphylaxis Is More Common with Rocuronium and Succinylcholine than with Atracurium
- Anaphylaxis to Neuromuscular-blocking Drugs: All Neuromuscular-blocking Drugs Are Not the Same
- Tranexamic Acid for Patients With Traumatic Brain Injury A Randomized, Double-Blinded, Placebo-Controlled Trial
Mechanical Ventilation
- Effect of Out-of-Hospital Noninvasive Positive-Pressure Support Ventilation in Adult Patients With Severe Respiratory Distress- A Systematic Review and Meta-analysis
- Prehospital Noninvasive Ventilation for Acute Respiratory Failure
- Sedation in non-invasive ventilation: do we know what to do (and why)?
- Tidal Volume and Mortality in Mechanically Ventilated Children- A Systematic Review and Meta-Analysis of Observational Studies
- Lung protection strategy as an effective treatment in acute respiratory distress syndrome
Other clinical conditions
- Effect of prehospital ultrasound on clinical outcomes of non-trauma patients—A systematic review
- Rate- and rhythm-control therapies in patients with atrial fibrillation- a systematic review
- Validation of a New Coma Scale, the FOUR Score, in the Emergency Department
- Anaphylaxis
- Fluid resuscitation in acute medicine: what is the current situation
- Treatment for calcium channel blocker poisoning- A systematic review
Non Clinical
- Free Open Access Medical education (FOAM) for the emergency physician
- Five Strategies to Effectively Use Online Resources in Emergency Medicine
- Open Access to Clinical Trials Data
- Revised standards for statistical evidence

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2016 NICE Major Trauma Guidelines. The pre-hospital recommendations.
21 FebNICE released the 2016 Major trauma Guidelines.
Many interesting recommendations where made for pre-hospital and in hospital providers about several topics
Airway management
Chest trauma
Haemorrage control
Circulatory access
Volume resuscitation
Fluid replacement
Pain management
Documentation
Training
Here is the Excerpt regarding the pre-hospital settings
Download the full guidelines for in-hospital recommendations and full description of Guidelines process and rationale behind every single recommendation
Download the full Guidelines at:
Major trauma: assessment and initial management
NICE guidelines [NG39] Published date: February 2016
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Tags: advanced airway management, clinical decision rules, emergency medicine, emergenza sanitaria territoriale, gestione avanzata delle vie aeree, Guidelines, litterature review, major trauma, medicina d'urgenza, medicina d'urgenza preospedaliera, NICE, prehospital emergency medicine, trauma