Ketamine use in Traumatic Brain Injury: Pool result are here!

18 Ott

Some weeks ago we pubblished this post:

I’m deeply convinced that Ketamine use in TBI is safe, and that the evidences against his use in patients with TBI are based on old and small case studies affected by major limitations.
The recent evidences that shown as Ketamine doesn’t race ICP, despite increasing MAP (thank god!), are based on small but well done trials and are as good (or even more) than the previous ones.
I’m also convinced that the utlity of Ketamine in sedation of severe injuried patients so much outweight the so lightly evidenced controindication in TBI, that his use is still mandatory in trauma patients who need emergency sedation.

 We launched the following pool

and here are the results

Pool result Ketamine in TBI

Click to enlarge




MEDEST you tube



2 Risposte a “Ketamine use in Traumatic Brain Injury: Pool result are here!”

  1. squartadoc1973 19 ottobre 2013 a 9:47 AM #

    Sottoscrivo a pieno. Direi che in Italia ove generalmente l’alternativa è il propofol o il midazolam la Ketamina è il farmaco che offre il miglior profilo per il trauma compreso quello cranico.
    Personalmente la utilizzo pressochè esclusivamente per l’induzione.
    Nella mia aneddotica esperienza credo che altre due cose che riguardano la Ketamina vadano un po’ limate.
    1)dosaggi: per la forma racemica il threshold dissociativo è 1mg/kg nella maggior parte dei pazienti ma non in tutti. Alcuni sono pienamente dissociati anche a dosaggi di gran lunga inferiori (0.4-0.5 mg/kg) e non parlo solo dei pazienti critici (shock, ipossia etc.)
    2) la preservazione del drive respiratorio: l’apnea è estremamente rara se la Ketamina viene somministrata lentamente (nell’arco di un minuto). Tuttavia raramente capita, anche senza considerare condizioni cliniche estreme, che pazienti, apparentemente sensibili, abbiano degli episodi di apnea anche protratti

  2. rfdsdoc 26 ottobre 2013 a 10:25 AM #

    Reblogged this on PHARM.


Inserisci i tuoi dati qui sotto o clicca su un'icona per effettuare l'accesso:

Logo di

Stai commentando usando il tuo account Chiudi sessione /  Modifica )

Foto Twitter

Stai commentando usando il tuo account Twitter. Chiudi sessione /  Modifica )

Foto di Facebook

Stai commentando usando il tuo account Facebook. Chiudi sessione /  Modifica )

Connessione a %s...

Questo sito utilizza Akismet per ridurre lo spam. Scopri come vengono elaborati i dati derivati dai commenti.


A Site for Intensivists and Resuscitationists


Supporting ALL Ohio EM Residencies in the #FOAMed World


Let's try to make it simple

thinking critical care

a blog for thinking docs: blending good evidence, physiology, common sense, and applying it at the bedside!


More definitive diagnosis, better patient care

Critical Care Northampton

Reviewing Critical Care, Journals and FOAMed

OHCA research

Prehospital critical care for out-of-hospital cardiac arrest


Education and entertainment for the ultrasound enthusiast




Emergency medicine - When minutes matter...

Songs or Stories

Sharing the Science and Art of Paediatric Anaesthesia


"Live as if you will die tomorrow; Learn as if you will live forever"


Navigating resuscitation

Life in the Fast Lane • LITFL

Emergency medicine and critical care education blog - Emergency Medicine Education

Our goal is to inform the global EM community with timely and high yield content about what providers like YOU are seeing and doing everyday in your local ED.

The Collective

A Hive Mind for Prehospital and Retrieval Med

Dave on Airways

Thoughts and opinions on airways and resuscitation science


A Free Open Access Medical Education Emergency Medicine Core Content Mash Up

Broome Docs

Rural Generalist Doctors Education


Emergency Medicine #FOAMed

"CardioOnline"Basic and Advanced Cardiovascular medicine" Cariology" concepts and Review -Dr.Nabil Paktin,MD.FACC.دکتـور نبــــیل "پاکطــــین

این سایت را به آن دکتوران و محصلین طب که شب و روز برای رفاه نوع انسان فداکاری می کنند ، جوانی و لذایذ زندگی را بدون چشمداشت به امتیاز و نفرین و آفرین قربان خدمت به بشر می کنند و بار سنگین خدمت و اصلاح را بدوش می کشند ، اهداء می کنم This site is dedicated to all Doctors and students that aver the great responsibility of People’s well-being upon their shoulders and carry on their onerous task with utmost dedication and Devotionاولین سایت و ژورنال انتــرنتی علـــمی ،تخـصصی ، پــژوهشــی و آمــوزشــی طبـــی در افغــانســـتان


Free Open Access Medical Education

Little Medic

Learning everything I can from everywhere I can. This is my little blog to keep track of new things medical, paramedical and pre-hospital from a student's perspective.

Prehospital Emergency Medicine Blog

All you want to know about prehospital emergency medicine

Italy Customized Tour Operator in Florence

Check out our updated blog posts at

EM Lyceum

where everything is up for debate . . .

Pediatric EM Morsels

Pediatric Emergency Medicine Education


Free Open Access Medical Education for Paramedics


Free Open Access Meducation 4 General Practice

Rural Doctors Net

useful resources for rural clinicians

Auckland HEMS

Unofficial site for prehospital care providers of the Auckland HEMS service




Prehospital Emergency Medicine

EM Basic

Your Boot Camp Guide to Emergency Medicine

KI Doc


Emergency Live

Prehospital Emergency Medicine


Academic Medicine Pearls in Emergency Medicine from THE Ohio State University Residency Program

Prehospital Emergency Medicine

 Academic Life in Emergency Medicine

Prehospital Emergency Medicine

Comments on: Homepage

Prehospital Emergency Medicine

Greater Sydney Area HEMS

The Pre-hospital & Retrieval Medicine Team of NSW Ambulance

%d blogger hanno fatto clic su Mi Piace per questo: